Thursday, September 26, 2019
MGM Journal Personal Statement Example | Topics and Well Written Essays - 250 words - 1
MGM Journal - Personal Statement Example In short, if we were to select two MGM tools as indispensible in the field, what would they be? With the ready help of information about a patient, the work of a physician gets much easier. And it does not only apply to a physician, but also to everyone working in the healthcare field. Access to important health information right on time will improve the efficiency and productivity, cutting down the average cost and nevertheless, make for a healthier world. Personal Health Record (PHR) guide is the just the tool for that purpose. The ultimate aim in medical profession is to achieve highest level of patientââ¬â¢s recovery, well being, and safety. Physician Practice Patient Safety Assessment (PPPSA) aims to increase the awareness and knowledge of the physician about the patientââ¬â¢s safety, thus creating a benchmark output for the physician. Better care and safety, lesser liability and better interaction is focused on to achieve higher level of performance and delivery on the part of the
Wednesday, September 25, 2019
Human Sexuality Coursework Example | Topics and Well Written Essays - 500 words
Human Sexuality - Coursework Example Media does not only have the power to gain support for a particular issue, it even has the ability to alter the current perception about an issue. Media has even impacted human beingââ¬â¢s perception of sexual harassment and rape related issues, they have been able to alter cases and opinions from favoring one individual to another. For example: Several newspaper articles reported that Kobe Bryant was not responsible for the charge of rape and those individuals who have gone through these articles clearly reflected same position through their perception. 3. The sexual offenders in US have almost a zero right to privacy, as soon as they are evacuated form the prisons and are allowed to live back in the community, their information is posted online so people can access this information and keep an eye on those who have been previously prosecuted as sexual offenders. Providing of information of sexual offenders to the common public is absolutely correct and lawful because sexual offences are cognitive in nature and an offender can commit the same crime. So in order to save the society from such offenders, transparency of information of the offenders is very
Tuesday, September 24, 2019
Public vs. Private Essay Example | Topics and Well Written Essays - 1500 words
Public vs. Private - Essay Example P 1992) It covers a great range of ideas and policies varying from the eminently reasonable to the wildly impractical.ââ¬â¢ The debate the paper delves on is what are the programs or sectors that are currently under the governmental supervision that can be privatized and what are the pros and cons of such privatization. Let us first look at some positive and negative facts and opinions from two sources in order to gauge the depth of the subject. Michael Williams in his article on Public Vs private pay, states the flaws in the current pay structure of an employee working for the US Postal service. Pointing out this difference in California where the average salary of a CalPers employee in 2004 for was about $46000 and the average of salary of all average per capita income of all Californians was $35000. Since then he says,ââ¬â¢ the gap has only expanded. He has proved this by stating the case of Postmaster General E Potter. ââ¬Å"Congress will hold a hearing next month into why Postmaster General John E. Potter has gotten a nearly 40 percent pay raise since 2006 and was awarded a six-figure incentive bonus last year, even as the U.S. Postal Service faces a multibillion-dollar shortfall that threatens a day of mail delivery. ALLISON SHELLEY/THE WASHINGTON TIMES REWARDED: Postmaster General John E. Potter received a compensation package totalling more than $800,000 for fiscal 2008.â⬠(Williams. M 2009) While the above information gives us a strong reason for privatization of the US postal service, the following facts will educate us on the public opinion of privatization. When privatization was at its full length and breadth under the Bush administration Congressman Jim Mc Dermott stated the following in one of the discussions ââ¬Å"It has become increasingly clear that the Bush Administration cares more about big business than about the average citizen. If this trend toward privatization continues, I worry that the privacy and
Monday, September 23, 2019
Aspects of Adaptive Leadership Essay Example | Topics and Well Written Essays - 500 words - 1
Aspects of Adaptive Leadership - Essay Example The various examples and cases discussed in the case study including that of the game strategy used by Earvin 'Magic' Johnson and Bobby Orr; helped in driving home the key message that leaders today are not only required to identify the critical challenges faced by the organizations posed by the external environment but must also orient the employees regarding such challenges and equip them with the task of adapting to the changes by reflecting on their day to day activities. Through various examples discussed in the case study, I learned the value of adaptive work and its relevance, especially in present day and age. This case study helped me in understanding the fact that in the absence of an adaptive work ethics in contemporary corporate environments, businesses risk the threat of extinction. Given the increasing competition brought about by globalization and technological advancements, conventional attitudes towards leadership and management it is imperative to replace convention al approaches to leadership with adaptive leadership. In conclusion, one of the most valuable lessons I learned via this case study is the fact that leadership entails a process of ushering in a generally unwelcome reality and motivating the employees and/or individuals to successfully adapt to it. It refers to the manner in which leaders coax the employees to unlearn the conventional work practices by guiding them to adapt their behavior in a way that helps them thrive in this extremely competitive and dynamic business environment.
Sunday, September 22, 2019
Discrimination and Young People Essay Example for Free
Discrimination and Young People Essay 1.1 Explain what is meant by * diversity * equality * inclusion Diversity means difference. It means understanding that each individual is unique, and recognizing our individual differences such as race, ethnicity, gender, sexual orientation, age, physical abilities and religious beliefs. Equality means treating everyone the same regardless of their individual differences. It is the discovery of these differences in a safe, positive, and nurturing environment. Everyone has an equal right to be treated with dignity and respect. No one should be denied opportunities because of their race or ethnicity, their disability, their gender or sexual orientation, their age or religion. Inclusion means including people in a way that makes them feel appreciated and respected. Treating individuals fairly and respecting the differences between them makes it easier to include them. 1.2 Describe the potential effects of discrimination Discrimination is treating someone or a group of people in a different way to everyone else based on their individual differences. It involves the behavior towards a child or children such as excluding or restricting children from activities that other children are participating in. Discrimination happens when we fail to respect individuals and their choices. Discrimination affects everybody in different ways: Low self-esteem, depression, withdrawn behaviour, shyness, tearful, fearful etc. When someone is discriminated against, it can exclude them from friends, family, neighbours, and society in general. A childââ¬â¢s self-worth is reduced, as they feel isolated, and alone. Childrenââ¬â¢s Young Peopleââ¬â¢s Workforce (2010 page 21) states that ââ¬Å"When children experience prejudiced attitudes, there is a danger of damage to their self-esteem and self-confidenceâ⬠. Discrimination can limit a childââ¬â¢s right to achieve their potential and objectives, their right to learn, their right to succeed. The most common forms of discrimination are racial remarks, being insulted and being the butt of hurtful jokes. Discrimination, racism and harassment may have significant mental and physical health consequences such as frustration, stress, anxiety and depression. Effects of discrimination physically and emotionally: Depression Anger Low self-esteem Isolation Loss of confidence Low self-worth Feeling stressed or unable to cope Fear of rejection The long-term effects could include: Loss of motivation Missed opportunities that may affect the childs experiences and development Limited access to services Mental illness caused by stress 1.3 Explain how inclusive practice promotes equality and supports diversity Inclusive practice is about the attitudes, approaches and approaches taken to ensure that people are not excluded or isolated. It means supporting diversity by accepting and welcoming childrenââ¬â¢s differences, and promoting equality by ensuring equal opportunities for all children. Child care workers show inclusive practice by working in ways that recognise, respect, value and make the most of all aspects of diversity. Childrenââ¬â¢s Young Peopleââ¬â¢s Workforce (2010 page 25) states that another type of inclusive practice is to ââ¬Å"offer children equality of opportunity toà participate, develop and learn. This does not mean treating them all the same; we have to acknowledge their diversity and treat children as individuals, with equal concernâ⬠. Having a sound awareness of and responding sensitively to an individualââ¬â¢s diverse needs supports them in developing a sense of belonging, well-being and confidence in their identity and capabilities and it helps them to achieve their potential to take their place in society. In addition, inclusive practice involves having an understanding of the impact that discrimination, inequality and social exclusion can have on an individualââ¬â¢s physical and mental health. Having such an understanding ensures appropriate, personalised care and support, thereby enabling an individual to develop self-respect and maintain a valued role in society. Childrenââ¬â¢s Young Peopleââ¬â¢s Workforce (2010 page 20) states that ââ¬Å"When children spend time in settings which promote diversity, equality of opportunity and inclusion, they are able to make progress in all areas of developmentâ⬠. Inclusive practice involves reflecting on and challenging oneââ¬â¢s own prejudices, behaviours and work practices. It also involves challenging those of colleagues and other service providers with a view to changing ways of thinking and working and changing services to build on good practice and to better support diversity and promote equality. Bibliography Authors:Penny Tassoni, Kate Beith, Kath Bulman, Sue Griffin Year of publication:2010 Title:Childrenââ¬â¢s Young Peopleââ¬â¢s Workforce ââ¬â Early Learning Childcare Publisher:Heinemann
Saturday, September 21, 2019
My Life Essay Example for Free
My Life Essay Above anything else, I still think that the most ambiguous term, concept, and thing in the world aside from its existence is life. A persons life can be the most difficult thing to describe, to define, to expound, and to measure. It will always be very challenging for an individual to summarize his of her entire life in nothing but words that do not even measure up to lifes vague beauty, wonders, and mysteries. But in the very best way that I can, combining everything I learned from writing, recounting history, and expressing my thoughts, I shall try to tell you what and how my life is so far. I will choose to tell how my life was in the past, what it is like now, and how I envision it to become in the future in my own tone and perspective. Simplicity is a very relative and subjective term. Some would associate this term with peace and serenity, but I would rather connect it with the ideas of non-extravagant beauty and non-chaotic momentum. And so, I would rather call my life a simple one in this sense. As for my childhood, I realized that this phase is not a completely natural incident and event which happens to everyone. In one way or another, and at least in my own life, I have come to understand that having a childhood is also partly an individual choice that people have to make. More importantly, having a happy childhood is the greater choice which people have to decide on whether they would have it or not. With regard to my own, I chose having a childhood and a worthwhile one. Twenty-three years ago, I cried meaningfully on the [insert date of birth; ex: 25th of December, 1986] which told my parents that I am already existing as a person. Throughout my entire childhood, I cried for various reasons ââ¬â whenever I got hurt, got disappointed, felt sad, felt annoyed, and felt overwhelmingly happy. All these cries, my life proved, are part of growing up. In my lifes context, these things made me realize that I am but a human being who feels and learns to express what he feels whenever he feels the need for it. Growing up in Turkey, I can say that my past is as colorful and vibrant as my country. My mind never ran out of iridescent and crazy ideas when I was going through my primary and secondary levels of education. I think I owe to my parents the considerable amount of effort they had to sacrifice in order to give me and my one and only sister the kind of education which we can both be proud of. My heart never skipped a beat as it vigorously lived with the glorious days of my childhood and adolescent years when I felt like I was the most powerful and liberated man that God has ever created. In a nutshell, my childhood is something I would always want to reminisce over and over again. And so, I rekindle that vibrant feeling every now and then, especially now that I write this chronicle of my life. Excellence and being well-molded never fascinated me until my parents, together with my mentors at the previous schools that I attended, injected into my consciousness the significance of education to an individuals betterment. I think that it safe to say that generally, young people dislike going to school very much; however, it was during those days, when I was on the verge of hating school, when I started to realize that education is actually the strongest foundation I could ever have that will equip me with the skills and knowledge to become a competent person in the future. As an average person who grew up with his parents in Istanbul, Turkey and who is still spending his days as a university student under the custody of his parents, I can say that I now have a considerably complete idea of what being a well-molded individual is like. Upon seeing and knowing successful people around me, I have to realize that all their authority, wealth, honor, valor come from a sufficient amount of education and dedication to it. But for me, aside from this, one thing which also aids in creating a well-molded individual in each person is his or her choice of submitting and staying under the guidance of his of her parents, for no parent shall wish for his or her child to go astray. And so, I chose to stay aligned with my parents guidance and proved to myself that indeed, parents have the innate ability to know the best and only the best for their children. I have never learned and realized the power of material things. I may have become fascinated with some, but one of the most amazing and valuable things I have learned in my life is that most of the things that can actually give true happiness to people are the intangible things that money cannot purchase in anyway. In several instances, I have also experienced the most typical emotional and psychological milestones that a human being goes through in life. As I entered adulthood, I have realized the value of true friendship and the value of having a special person caring for me. I have also been able to go through several rites of passage that defined my membership to the so called ââ¬Å"in-circlesâ⬠in my youth. Many times I fell hard and stood up again, never surrendering to the most miserable heartbreaks yet the most meaningful lessons that I can consider indispensable for the rest of my life. Truly, no material form of wealth and luxury can ever compare to the most special things that I regard as my greatest achievements in my life so far; and these include my self-dignity, the seemingly everlasting friendship that I share with my peers, the love I constantly receive from the people around me, and the bright future that shines ahead of me in this point of my life. I chose to value these intangible treasures that will last longer than me and than the ones that will fade after I passed. Yet, no matter how colorful or pleasant my writing will turn out to be, I also believe that life is not always a bed of roses. For several instances, I have received harsh criticisms from people who tried to judge me from a far and tried to measure me as a person without knowing me completely. I have faced several failures that brought me serious humiliation and deep self-disappointment. I also have failed to live up to other peoples expectations a number of times. At one point, I thought these falls were bound to identify and label me as an individual and as a man. But my hopes, aspirations, and visions inside of me that have been kept hidden behind these failures always manage to float above everything else and take over my consciousness. Thus, I chose to believe that I as an individual can only be judged and measured according to how strong and triumphant I succeeded after a fall and not by how hard I fell flat on the ground. I chose to tell you this tale of my life in my endeavor to give myself a hint on how I would want to envision myself in the future. If there is one thing this chronicle has taught me and made me understand about myself, it is that my life is truly made up of great choices, and each choice is a fruit of a trial-and-error process of learning. Right now, the life of being a university student is giving me all the positive thoughts of what my life ahead would become. I could be successful like todays powerful and affluent people, yes I can say, but I would choose to follow this tale and make a success story of my own, keeping in mind all the vibrant memories I have had from my childhood, all the valuable lectures my parents and my mentors taught me, the inspiration that my sister, my friends, and loved ones gave me, and the indispensable lessons my failures made me realize. Most especially, I would choose to remember my own ambiguous yet insightful definition of what my life is right now and what it will be tomorrow. Thus, I would still choose, and in the future, I know there will still be more choices to make, but I guess that is what life is to me basically ââ¬â a never-ending ball of choices which define who we are.
Friday, September 20, 2019
Herbal Products Market Research
Herbal Products Market Research Abstract: Herbal products have gained a lot of attention in the recent years. This has pushed natural and nutraceuticals companies globally to take interest in these products. Herbal extracts are no longer a concoction of plants but are sophisticated standardized extracts. This has led countries all over the world to set regulatory guidelines and policies in order to maintain good quality, standardized herbal medicines. Konark Herbals Health Care, an India based company, manufactures solid and liquid herbal extracts in semi finished form. The company recently has decided to launch its products globally. This project focuses on opportunities of herbal products in the European Market i.e. the European Union. Europe being the central hub of herbal medicines is integrated with a number of regulatory guidelines set by the EU. The project aims at understanding these regulatory policies, gauging the market scenario and presenting ideas for launching the companys products by creating its place in the market. The main objective of this project was to gain an understanding of the herbal products already in the market and finding newer opportunity for its use Introduction About the Company Konark Herbals and Healthcare is a medium sized company established in 2004. The company is into manufacturing and selling of semi finished herbal products. These products include soft and dry herbal extracts, in both solid and liquid form. The company is also associated with the Konark Research foundation which carries out all the quality assurance and testing to ensure quality and standardised products. Konark manufactures over 300 herbals extracts, though its flagship product is curcumin and its derivatives. Up until 2010 the companys main focus was the domestic market. The products were marketed and sold either for domestic use or to other Indian companies for export purposes. The main problem faced by Konark was the competitive prices. The company also found that since the regulations in India were not very strict most competitive suppliers would sell sub standard quality products at a cheaper rate. A thorough study was done to understand the pros and cons of focusing on the domestic market. Therefore Konark Herbals and Health Care decided to launch its products globally. Therefore, this report focuses on opportunities of herbal products in the European market. Traditional Medicine has always had its popularity worldwide. In addition over the last few years there has been increase in the use of complementary and alternative medicines (CAMs) in many developed and developing countries. The last 15 years have seen an increase in the popularity of plant based medicines in the western world. Therefore the safety and quality of the CAMs have become very important concerns for the health authorities as well as the public. Several traditional medicine practices have been developed over the centuries in different cultures but without a parallel advance of international standards and using inappropriate methods for evaluating traditional medicine. Therefore strict guidelines and policies for herbal medicines are critical to the continued existence of quality products. Even though India and China are known for their herbal medicines since centuries, the hub of herbal products is Europe. More than 60% of the Europeans and greater than 80% of Germans (Figure 1) have used herbal products at some point of time in their life. Herbal remedies which we earlier sold in small special shops, often without any license, have now become mainstream drugs manufactured by multinational companies and sold in pharmacies throughout Europe. It is due to this high usage of products that the European Union has an extensive set of guidelines for herbal products. The EU has laid down guidelines and policies for all the processes related to these herbal products from manufacturing right up to market authorization and which it expects all to adhere to. European Union Overall Market Size The member states of the European Union represent the largest single commercial market for herbal drugs and medicinal plants in the world. The European market for herbal supplements along with herbal medicines is currently at $7.4billion. An analysis based on the data from IMS health placed the global European over the counter (OTC) market for herbal medicines at approximately $5billion. Imports The EU is also the largest importer of Crude medicinal plants and herbal extracts with imports approximated at around 100,000 tonne. This is almost double the quantity imported by the USA (IMS report). Germany is the most important European importer with 40% of the European market followed by France and Italy. European Guidelines Europe consists of 50 countries. And each country has its own regulatory guidelines and policies. It is important to know that out of the 50 countries only 27 countries fall under the European Union. Legislation in the European Union is set at the EU level, but there may be (additional) legal requirements which may be country specific. Although maximum synchronization is aimed it is not always achieved because of negotiations, debates and national interest. The European Medical agency along with the THMPD (Therapeutic herbal Medical product directive) are the two many regulatory bodies within the European Union. Each of the two bodies has a set of guidelines which has to be followed by not only the companies within Europe but also the companies that want to enter the European market for business opportunities. It includes policies from cultivation right up to marketing of the product in Europe. Understanding these guidelines is necessary for Indian companies such as Konark Herbals H ealth Care because in order to enter the European markets, they need to abide by them. The committee on Herbal Medicinal products (HMPC) HMPC, a part of the European Medical Agency, is responsible for preparing the agencys opinions on herbal medicines. In 2004 it replaced the proprietary medicinal products working party on herbal products which introduced a simplified registration procedure for herbal drugs in EU member states. The committee has the responsibility to prepare monographs of well established herbal medicines which is based on evaluation of available scientific data or on its traditional use in the European community. The monograph includes uses, safety information and information on undesirable effects. Traditional Herbal Medicinal Product Directive (formerly The Directive 2004/24/EC) The THMPD was established in 2004 to provide a simplified regulatory approval process for traditional herbal medicines in the EU. Under this regulation all herbal medicinal products are required to obtain an authorization to market within the EU. As per the THMPD all products marketed before this legislation came into force can market their product till 30 April, 2011. Once this limit expires they must gain market authorization. These guidelines are of great importance especially during the audits done by the European companies. As a mandatory procedure, all European companies conduct a thorough audit of the manufacturing facilities of the suppliers to check them for GMP compliance. The audit even checks for Good Agricultural practices (GAP) complied by the farmers supplying the crude plants to the supplier. GAP includes various documents and certificates that the supplier must have from the farmers. In case any of the guidelines are not met with, the supplier is not only rejected but is blacklisted by the company for future purposes until such time that the supplier has proven to be GMP and GAP compliant. Therefore the suppliers cannot afford to make any mistakes Examples of EU legislations relevant for herbal products: Directive 2001/83/EC on marketing authorization for medicinal products for human use, including homeopathic products and herbal medicines. Directive 2003/94/EC on the principles and guidelines of GMP for medicinal products for human use Phytosanitary measures. Directive 2000/29/EC Regulation 338/97 on the protection of endangered species in trade, CITES Preventive measures on organisms harmful to plants Directive 2000/29/EC Country Profiles Out of the 27 countries belonging to the European Union few countries such as Germany, UK and France are the major markets for herbal products. As mentioned earlier EU legislations are set at the EU level, but there may be country specific (additional) legal requirements. Understanding the guidelines for each of the countries is crucial because it is through these countries that Indian companies will make their entrance into the European Herbal Markets. Germany: Germany by far is the most important consumer of plant based medicines in Europe which accounts for more than 50 % of all European licensed herbal product sales. It is also the largest producers of herbal phytomedicines. Cultivation in Germany has declined massively over the years, which has lead companies to import herbal extracts from other countries such as India and China. This proves advantageous for Indian companies. It is also important to notice that even though Germany does have domestic cultivation, only 5% 10 % of the total requirement is covered by the domestic production. Germany is by far the largest importer of medicinal plants and extracts with imports of around 50,000 tonnes on a yearly basis. The basis of market authorization in Germany has been laid out in the Second Medicines Act which was formed in accordance with the EU legislative framework. It required a review of the safety and quality of 300 plants. This was done by a team of experts known as the Commission E who published more than 235 medicinal plants. Germany is one of the very few countries that consider herbal products as medicines thereby providing complete reimbursement of such products. The herbal drugs are reimbursable by the health insurance system unless special criteria for their exclusions apply. These exclusions are due to negative assessment by commission E. There are 380 monographs presented in the American Botanical CouncilsÃâà The Complete German Commission E Monographs, Therapeutic Guide to Herbal Medicines, which has recently been translated into English The monographs include lists of approved and unapproved herbs, uses, indications, side effects, interactions of herbs with conventional drugs and duration of administration German Regulations: A national pharmacopoeia, the Deutsches Arneibuch and the European Pharmacopoeia are used, both of which are considered to be legally binding. A number of additional monographs have also being issued such as the Deutcher Arzneimittel Codex but are not legally binding. Regulatory Requirement for the manufacture of herbal medicines include adherence to the information in the pharmacopoeias. In the absence of pharmacopoeias, monographs, the GMP rules for conventional pharmaceutical, German Medicines Act and the Eudralex. Compliance with these requirements is ensured through inspection. Herbal medicines are sold in Germany in pharmacies as OTC and prescription medicines in special outlets and supermarkets. Advantages for an Indian Company to supply to German companies: Not more than 10% of the total requirement is covered by domestic market Only a handful of herbal plants are cultivated in Germany as compared to India. As per the adapted from BAH (Figure 2) more than a 100 Indian medicinal plants can cater to these therapeutic categories. Many Indian plants such as curcumin, Amla, Ashwagandha or on the positive list of commission E. Several curcumin products are reimbursed by the health insurance system. France: France is both a major producer and consumer of medicinal plants. It is the second largest market in Europe after Germany. It has more than 4000 hectares under cultivation of which over 30% is dedicated to plants such as thyme fennel chamomile and peppermint. Southern France is a major market for essential oils and aromatherapy. France imports around 30,000 tonnes of medicinal plants and extracts from countries such as India and China. France is also an exporter of medicinal plants which is about 8000 tonnes on a yearly basis. Most exports are simply intra European consignments often within same company. French regulations make it difficult to sell unlicensed herbal remedies. Around 527 medicinal plants are listed in the French Pharmacopoeia of which 454 plants are contained in list A (positive benefit /risk ratio). These include plants such as acacia. Curcumin, Aloe Vera etc. Plants such as tobacco and Thuja fall under list B that has a negative benefit/risk ratio. Despite all this, herbal medicines are classified as medicines in France and are subject to market authorization under the Health ministry. Guidelines: The French Republic does not have any national policy, laws, expert committee or national research institute on traditional medicines. Herbal medicines are regulated as OTC medicines and by law claims may be made about them. The same GMP rules for manufacture are applicable for herbal medicines as for the conventional medicines. Compliance with the requirements is ensured through inspections. Safety requirements are the same as that for conventional drugs. Out of 787 medicines registered none, are listed on national essential drug list. Advantages for Indian companies to target France: France is the Hub for essential oils and aromatherapy products. Therefore many Indian companies can supply oils such as cinnamon oil, turmeric oil etc. Out of the plants listed in List A of the French Pharmacopoeia more than 250 plants are available in abundance in India. Although the government is coming up with newer policies, cultivation in France is only for a minor group of medicinal plants. Therefore French companies have to look at supplier of plants and extracts. United Kingdom United Kingdom (U.K.) has until recently been well below that of many European counties. U.K. based MNCs have given limited importance to research in herbal drugs. British farmers too have not given much importance to medicinal plants. Less than 2000 hectares are devoted to medicinal plants. But consumption of herbal medicines has been growing at the rate of 10% (WHO report, 2008) Although U.K. has no single national office, the medicines and Healthcare product regulatory agency and the department of health in England have numerous teams to develop policy on the safe use and practice of traditional medicines. Herbal medicines are regulated under Medicines Act 1968 (2001/83, EC also applies). Until 2011 the directive provided two regulatory routes for herbal medicines to reach the market i.e licensed herbal medicines and unlicensed herbal medicines. Since May 2011 unlicensed herbal medicines have been ban in the market. The British Pharmacopoeia contains 124 national monographs. There are around 500 licensed herbal drugs in the U.K. but none are included in the national essential list. Herbal drugs are sold in pharmacies as OTC and prescription medicines. Overview of the top diseases affecting European human population Chronic diseases are the main cause of mortality in Europe. Research (by EDEC) suggests that complex conditions such as diabetes, depression and dementia will impose a prominent burden in the future. Some years ago chronic diseases were considered to be a problem of only the rich and elderly people. But today we know that which high income countries, poor as well as young people are affected by these chronic diseases. The implications of the diseases are also very serious. There are a number of chronic diseases that affect people all over Europe. The most prevalent ones are: Depression Obesity Diabetes Mellitus Alzheimers disease Parkinsons disease Dementia Schizophrenia COPD The link between disease and age is crucial from an economic public policy standpoint. The proportion of Europeans aged 65 years and older is projected to grow from 15% to 23% by 2030. This trend is clearly one of the many reasons for the growing burden of chronic diseases in Europe. (Pomerleau, Knai and Nolte, 2008). The prevalence of mental disorders is very high in Europe. Dementia amongst those who are aged i.e. 65 and above, in 2000 was estimated to vary between 6% to about 8 %. WHO has estimated that one in five persons will develop depression and each year 33 million European suffer from major depression. In 2008, the rates were lowest in Spain, Greece and Portugal while the highest estimates were for Finland, Israel, Belgium and France. Suicide from depressive disorders is the third leading cause of death among young Europeans. Top diseases affecting livestock in Europe Novel strategies and responses are necessary to meet the economic and human health risks that are associated with livestock diseases. Human-health threats from livestock come in two basic forms: (i) zoonotic diseases, and (ii) food-borne illnesses. Zoonotic diseases are those diseases that arise in animals but can also be transmitted to humans. Potentially pandemic viruses, such as influenza, are the most newsworthy, but many others, including rabies, brucellosis and anthrax also do exist. Food-borne illness can come from disease agents such as salmonella and E. coli. Highly pathogenic livestock diseases remain alarming for the people of Europe because: They are still highly pathogenic for humans. They are continuing to evolve. There is a risk of generic recombination with the viruses that are better adapted to, and can be easily transmitted among humans. The diseases affecting livestock in Europe include: Livestock Disease Avian influenza Bovine Tuberculosis Rabies Bovine Brucellosis Transmissible spongiform encephalopathies (TSE) Ovine and Caprine brucellosis (B. Melitensis) Salmonellosis (zoonotic salmonella) Livestock Disease Avian influenza Ovine and Caprine brucellosis (B. Melitensis) Salmonellosis (zoonotic salmonella) African Swine Fever Bluetongue (High risk endemic areas) Methodology The main product to be launched by the company being Curcumin and its various derivates, a secondary research was conducted to gain an understanding about the product. Such a research gave an idea about its current use globally. Various companies across the globe are already manufacturing curcumin products and supplements therefore the product per se is not a novel product. But by understanding its current use it is possible to point out the areas that have never been explored. Companies such as Indena, Sabinsa, and Sigma Eldrich have been selling curcumin supplements over a decade. But it is astonishing to see that even today the full potential of curcumin and its derivatives has not been realized. This gives a possibility for companies to use such products for newer diseases. Reviewing diseases affecting Europe serves great importance since it explains the need for drugs in those sectors and consequentially the unmet medical need. About Curcumin Curcumin is a hydrophobic polyphenol derived from a the rhizome Curcuma longa (Turmeric). It is a gold-coloured spice frequently used in India, not just for health care but also for the preservation of food and as a dye for textiles. Since the time of Ayurveda (1900BC) numerous therapeutic actions have been assigned to curcumin for a selection of diseases, including skin diseases, pulmonary, and gastrointestinal systems, wounds, sprains, allergies and liver disorders. It is in the last few decades that curcumin has gained a lot of attention by researchers, scientists and nutraceuticals companies worldwide. It is due to this, that there have been more than a hundred experiments been conducted in animals and plants for various diseases. Konark Herbals and Health Care has a vast portfolio of curcumin extracts of various standards. The company manufactures the extract from 1% curcuminoid content up to 99% curcuminoids. KHHC products Curcuma longa powder extract (Total curcuminoids NLT 95% by HPLC/UV spectrophotometer) Curcuma longa powder extract (Total curcuminoids NLT 40% by HPLC/UV spectrophotometer) Curcuma longa powder extract (Total curcuminoids NLT 10% by HPLC/UV spectrophotometer) Curcuma longa Granular (Total curcuminoids NLT 95% by HPLC/UV spectrophotometer) Curcuma longa Granular (Total curcuminoids NLT 85% by HPLC/UV spectrophotometer) Uses There have been various trials conducted for a wide variety of diseases most of which have been successful but have not received their due. Below is a short summary of the various uses of curcumin Neurological Disorders: Curcumin being a potent anti inflammatory agent has found its use in a number of diseases. Various trials have been conducted for its use against several neurological disorders. Current treatments for the majority of these diseases have not succeeded adequate until now. Both of oxidative damage and inflammation have been proved as having roles in age-related neurodegenerative diseases. Because of its pluripotency, oral safety, prolonged history of use, and low cost, curcumin has huge potential for the prevention of numerous neurological conditions for which present therapeutics are less than optimal. Parkinsons disease Alzheimers disease Schizophrenia Depression Oncology: It has been proved that curcumin is an anti oxidant. This property of the molecule has allowed it use for several diseases such as diabetes mellitus, obesity, and metabolic syndrome. The anti oxidant property has potentiated its use even in the field of oncology which today is by far the most researched therapeutic category. Studies done on animals and humans have proved promising in more than just one type of cancer. There have been a number of articles published in journals all over the world regarding its potential use against prostate cancer, pancreatic cancer breast cancer and even blood cancer. Antibacterial Activity: Yet another property of curcumin is its proven use in the antibacterial and antifungal category. Curcumin was known to have antibacterial property since centuries but only recent experiments and research have proved its antibacterial activity. This has not only interested physicians but also veterinarians in potentially using curcumin as a topical drug. Patents The according to the Intellectual property rights, the use of curcumin cannot be patented since it is protected by traditional Knowledge of the country. But there have been several patents granted for novel drug delivery system of curcumin. The reason for modifying the molecule developing new delivery systems is because curcumin is a hydrophobic molecule and hence it has a low bioavailability. In order to over this problem researchers have formulated various novel systems to enhance its bioavailability. Understanding the current patents held for curcumin is needed because it shows how advance the industry is. A list of a few patents has been given below Water soluble curcumin based compounds , US patent application Curcumin Dextrin combinations, US patent application Buccal Drug Delivery System for Curcumin, US patent application Vaginal drug Delivery of curcumin, US patent application Spray freeze dry for pulmonary administration, US patent application Potential launch of curcumin products for Diabetes Mellitus Type 2: Diabetes is a chronic disease that arises when the pancreas does not produce enough insulin, or when the body cannot effectively use the insulin it produces. This leads to raised glucose levels in the blood and can cause long-term damage to the body and failure of various organs and tissues. Currently about 55 million Europeans are affected by diabetes Mellitus type 2. Studies conducted at research institutes have proven the effect of curcumin against diabetes. A comprehensive study was done on the diseases and the use of curcumin against various symptoms of the disease. A matrix approach was taken up. (As suggested by Dr Arun Bhatt, Clininvent) With the help of secondary research it was observed that curcumin can treat almost all symptoms relating to diabetes. Various poly herbal formulations are also in the development stage at Konark herbals and health care which have the potential to treat diabetic conditions. Through the research it was observed that several herbs in combination with curcumin could be used against the diabetic symptoms. Curcumin also has shown positive results for reducing cholesterol and LDL levels in the body i.e. preventing obesity. This can give curcumin an opportunity to act as a drug for pre diabetic syndrome. This can have a much better market since it has been observed that the trend amongst more people globally is cha nging from illness to wellness. Effect Potential Cure Eyes and vision Retinopathy caused due to oxidative stress and inflammation Cataract- does not prevent but delays its occurrence. Curcumin Feet and skin Foot ulcers. Polyherbal formulation (on going RD at Konark ) Joint pain osteoarthritis Osteoporosis- Curcumin , curcumin + Ashwagandha Oral Gum diseases Curcumin , curcumin + neem Curcumin in the form of THC Dry mouth Anti bacterial effect of curcumin Gingivitis Antibacterial effect s of curcumin Complications Alzheimers disease Curcumin, Melissa officinalis, ashwagandha, tinoprora cordifolia Cancer Prostate cancer Breast Cancer Colon Cancer Curcumin Cholesterol Metabolic syndrome Curcumin UTI Curcumin +boswelia antibacterial activity Further work remaining in the project: Potential launch of product for various diseases Speaking with the experts SWOT analysis Marketing strategies 4Ps Barriers to entry and overcoming challenges References: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/landing/vet_epar_search.jspHYPERLINK http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/landing/vet_epar_search.jspmid=WC0b01ac058008d7a8HYPERLINK http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/landing/vet_epar_search.jspmid=WC0b01ac058008d7a8mid=WC0b01ac058008d7a8 http://www.imb.ie/EN/Human-Medicines/Human-Medicines/Traditional-Herbal-Medicines-Registration-Scheme.aspx http://www.nutraceuticalsworld.com/issues/2008-07/view_features/the-global-herbs-amp-botanicals-market/ http://www.anh-europe.org/node/3113 http://www.turmeric-curcumin.com/ http://www.research.ucla.edu/tech/ucla02-427.htm http://onlinelibrary.wiley.com/doi/10.1002/jps.22512/abstract http://www.medscape.com/viewarticle/754681 http://www.clininvent.com/clininvent/Publications/Complementary%20medicine%20Need%20for%20a%20balanced%20approach%20-%20Heal~1.htm http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929771/
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